| United States Patent | 5,243,038 |
| Ferrari, et. al. | Sept. 7, 1993 |
| Inventors: | Ferrari; Franco A. (La Jolla, CA); Richardson; Charles (San Diego, CA); Chambers; James (San Diego, CA); Causey; Stuart C. (Del Mar, CA); Pollock; Thomas J. (San Diego, CA); Cappello; Joseph (San Diego, CA); Crissman; John W. (San Diego, CA). |
| Assignee: | Protein Polymer Technologies, Inc. (San Diego, CA). |
| Appl. No.: | 114,618 |
| Filed: | Oct. 29, 1987 |
| Continuation-in-part of Ser No. 927,258, Nov. 4, 1986, abandoned. |
| Intl. Cl. : | C12N 15/11, C12N 15/62, C07K 13/00 |
| Current U.S. Cl.: | 536/23.1; 435/69.1; 435/172.3; 435/320.1; 530/353; 536/23.4; 935/10; 935/60 |
| Field of Search: | 435/320, 68, 172.3, 91, 252.3, 69.1, 320.1; 350/353; 536/27, 22.1, 23.1, 23.4; 935/10, 60 |
| 4,132,746 | Jan., 1979 | Urry et al. | 525/432 |
| 4,187,852 | Feb., 1980 | Urry et al. | 600/36 |
| 4,474,851 | Oct., 1984 | Urry | 428/373 |
| 4,500,700 | Feb., 1985 | Urry | 528/328 |
| 4,589,882 | May, 1986 | Urry | 623/11 |
| 5,149,657 | Sept., 1992 | Maugh et al. | 435/69.1 |
| 2162190A | Jan., 1986 | GB |
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Primary Examiner: Schwartz; Richard A.
Assistant Examiner: Mosher; Mary E.
Attorney, Agent or Firm: Rowland; Bertram I.
Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.
The government has certain rights in this invention as a result of support provided by the Department of the Navy for the work leading to the present invention.
