| United States Patent | 5,606,019 |
| Cappello | Feb. 25, 1997 |
| Inventors: | Cappello; Joseph (San Diego, CA). |
| Assignee: | Protein Polymer Technologies, Inc. (San Diego, CA). |
| Appl. No.: | 212,237 |
| Filed: | Mar. 11, 1994 |
| Continuation-in-part of Ser No. 609,716, Nov. 6, 1990, Pat. No. 5,514,581 and Ser No. 53,049, Apr. 22, 1993, abandoned, which is a continuation-in-part of Ser. No. 114,618, Oct. 29, 1987, Pat. No. 5,243,038. |
| Intl. Cl. : | C07K 7/06, A61K 38/00, A61K 38/17 |
| Current U.S. Cl.: | 530/329; 435/69.1; 435/172.3; 435/273; 435/320.1; 530/330; 530/353 |
| Field of Search: | 530/353, 329, 330; 435/69.1, 320.1, 122.3, 273; 623/11; 514/12 |
| 4,215,200 | Jul., 1980 | Miyata et al. | 435/273 |
| 4,589,882 | May, 1986 | Urry | 528/328 |
| 5,243,038 | Sept., 1993 | Ferrari et al. | 536/23.1 |
Computerized Printout CA119:27323 (1995) of EP.488687 Reg. No's 151500-11-7and 151500-12-8.
Brennan, "Fibrin Glue," Blood Reviews (1991) 5: 240-244.
Nissen et al., "Fibrin Glue in Otology and Neurotology," Am. J. of Otology(1993) 14: 147-150.
Francis & Marder, "Physiologic Regulation and Pathologic Disorders of Fibrinolysis," Human Pathology (1987) 18:263-274.
Frykman, "The Quest for Better Recovery from Peripheral Nerve Injury,"J. of Hand Therapy (1993) Apr.-Jun. 1983-1988.
Greenberg et al., "Transglutaminases: Multifunctional Cross-LinkingEnzymes that Stabilize Tissues," The FASEB Journal (1991) 5:3071-3077.
Rixon et al., "Nucleotide Sequence of the Gene for the y Chain of HumanFibrinogen," Biochemistry (1985) 24: 2077-2086.
Terris & Fee, "Current Issues in Nerve Repair," Arch OtolaryngolHead Neck Surg. (1993) 119: 725-731.
Primary Examiner: Lilling; Herbert J.
Attorney, Agent or Firm: Rowland; Bertram I.
Copolymers are provided having varying ratios of elastin and fibroinrepeating units. By varying the length of segments of the elastin and fibroinrepeating units, the absorption can be greatly varied. Tensile strengthsremain relatively constant regardless of the composition within the prescribedranges. The copolymer compositions and recombinant fibroin can be usedfor the production of a wide variety of formed objects and amorphous massesfor use as implants.
