| United States Patent | 5,641,648 |
| Ferrari, et. al. | Jun. 24, 1997 |
| Inventors: | Ferrari; Franco A. (La Jolla, CA); Cappello; Joseph (San Diego, CA); Richardson; Charles (Florence, MT). |
| Assignee: | Protein Polymer Technologies, Inc. (San Diego, CA). |
| Appl. No.: | 175,155 |
| Filed: | Dec. 29, 1993 |
| Continuation-in-part of Ser No. 53,049, Apr. 22, 1993, abandoned, which is a continuation of Ser. No. 114,618, Oct. 29, 1987, Pat. No. 5,243,038, and a continuation-in-part of Ser No. 609,716, Nov. 6, 1990, Pat. No. 5,514,581, which is a continuation-in-part of Ser. No. 269,429, Nov. 9, 1988, abandoned, which is a continuation-in-part of Ser. No. 114,618, Oct. 29, 1987, Pat. No. 5,243,038, which is a continuation-in-part of Ser. No. 927,258, Nov. 4, 1986, abandoned. |
| Intl. Cl. : | C12P 21/02, C12N 15/11, C07H 21/00, C07H 21/04 |
| Current U.S. Cl.: | 435/69.1; 435/71.2; 435/172.1; 435/252.8; 435/320.1; 536/23.1; 536/24.1; 536/25.3 |
| Field of Search: | 435/69.1, 71.2, 172.1, 320.1, 252.8; 536/23.1, 24.1, 25.3 |
| 5,089,406 | Feb., 1992 | Williams et al. | 435/172.3 |
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Primary Examiner: Fleisher; Mindy
Assistant Examiner: Degen; Nancy J.
Attorney, Agent or Firm: Flehr Hohbach Test Albritton &
Herbert LLP
Methods are provided for the production of large polypeptides containing repeating sequences of amino acids utilizing biochemical techniques, specifically DNA sequences coding for the expression of the large polypeptides. Systems utilizing exogenous transcriptional and translational regions to control the production of the large polypeptides are also provided.
The government has certain rights in this invention as a result of support provided by the Department of the Navy for the work leading to the present invention.
