| United States Patent | 5,773,577 |
| Cappello | Jun. 30, 1998 |
| Inventors: | Cappello; Joseph (San Diego, CA). |
| Assignee: | Protein Polymer Technologies (San Diego, CA). |
| Appl. No.: | 397,633 |
| Filed: | Mar. 2, 1995 |
| Continuation-in-part of Ser No. 205,518, Mar. 3, 1994, abandoned. |
| Intl. Cl. : | C07K 14/00, A61K 38/00 |
| Current U.S. Cl.: | 530/350; 424/77; 424/422; 424/484; 424/486; 435/172.3; 530/353; 530/356; 530/357; 530/360; 530/402; 530/409 |
| Field of Search: | 424/77, 94.5, 422, 484, 486; 435/172.3, 193; 514/2, 19; 530/350, 353, 356, 357, 360, 402, 409 |
| 5,049,506 | Sept., 1991 | Stuber | |
| 5,243,038 | Sept., 1993 | Ferrari et al. | 536/23.1 |
| 5,316,934 | May, 1994 | Kobayashi et al. | 435/215 |
| WO90/05177 | May, 1990 | WO |
Traore, F. et al. J. Agric. Food Chem. 39:1892-1896 (1991).
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Kagan et al., "Influence of Sequence and Charge on the Specificity of Lysyl Oxidase toward Protein and Synthetic Peptide Substrates," J. Biological Chemistry (1984) 259: 11203-11207.
Pattanaik et al., "Phophorylation and Dephosphorylation Modulation of an Inverse Temperature Transition," Biochemical and Biophysical Research Communications (1991) 178: 539-545.
Sierra, D. H., "Fibrin Sealant Adhesive Systems: A Review of their Chemistry, Material Properties and Clinical Applications," J. Biomat. App. (1993) 7: 309-352.
Primary Examiner: Patterson, Jr.; Charles L.
Assistant Examiner: Stole; Einar
Attorney, Agent or Firm: Trecartin; Richard F. Flehr Hohbach
Test Albritton & Herbert LLP
Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences, capable of enzyme catalyzed covalent bond formation for cross-linking, as exemplified by glutamine and/or lysine reactive for FXIII catalyzed isopeptide formation or non-amino acid polymers having side chains comprising such amino acids or sequences, which may be used for preparation of articles of manufacture, particularly cross-linkable compositions. By appropriate choice of the polymer, resorbable implantable polymers may be used in internal applications for mammals as formed objects or depots.
